Use of generic versions of direct-acting antivirals resulted
in very high cure rates for people who obtained the products through three
buyers’ clubs, indicating that the generic products are effective, according
to three presentations at the International Congress on Drug Therapy in HIV
Infection (HIV Glasgow) this week.
People who purchased the drugs were cured of hepatitis C at
a cost of around $700-$900 in South-East Asia and Eastern Europe, Dr Andrew Hill of St Stephen’s AIDS Trust, London,
reported in three poster presentations at the conference.
Direct-acting antivirals typically cure 90 to 95% of hepatitis
C infections, even in cases where people have advanced liver disease or
previous experience of ineffective treatment. The price of treatment remains a
major barrier to curing hepatitis C for millions of people, and where rationing
of treatment, lack of health insurance or lack of a national treatment
programme deny access to these drugs, people are turning to internet-based
buyer’s clubs to obtain generic versions of direct-acting antivirals.
Generic versions of direct-acting antivirals are
manufactured in India under voluntary license from Gilead Sciences, and by
other Indian companies who are not licensees, and in other countries such as
Bangladesh where patents on the products do not exist. The lack of patent
protection allows generic manufacturers to produce their own versions of the
drugs. In many countries it is legal to import drugs for personal use by
ordering them online. In other countries imports of generic
drugs are restricted to those carried through customs by individuals in
quantities sufficient for personal use.
study by Dr James Freeman of Hobart, Australia, showed very high
when using generic versions of direct-acting antivirals, and also provided evidence that the
products purchased contained the necessary levels of active drug. The
presented this week, in which data supplied by patients and their
physicians were analysed by St Stephen’s AIDS Trust in London, measured
virological responses. Two studies identified the generic products used,
and one study
was able to measure levels of active ingredients. The preliminary
the three studies show cure rates comparable to those achieved with